Congratulations to Ziwei and Arjun on their work engineering the expression systems of OrthoRep. This work, just accepted at ACS Synthetic Biology, shows that new promoters and hard-coded polyA tails can increase the expression of genes on the orthogonal plasmid by up to ~40-fold over what we could previously attain, almost reaching the strongest expression levels of genomically-encoded genes. Now, OrthoRep should be able to evolve genes requiring low or high levels of expression, and anything in between!