OrthoRep paper published in Cell

Congrats to Arjun, Garri, Muaeen, and Alex for their latest work on supercharging evolution, just out in Cell! Our OrthoRep system is now continuously and stably evolving user-selected genes at mutation rates 100,000-fold higher than the cells normally use, crossing a speed limit that host genomes can’t theoretically exceed. We show how evolution with OrthoRep can be used to uncover interesting features of drug resistance in a malarial drug target. Rapid, scalable evolution of protein therapeutics and valuable metabolic enzymes are successfully underway in the lab. Click here for the UCI news story.