CHYRON preprint!

Congratulations to Theresa, Joey, Mason, Courtney, Guohao and our collaborators for developing CHYRON, a single-site DNA recorder that autonomously marks lineage and logs signals in human cells. CHYRON uses an hgRNA + Cas9 + TdT to write random bits of insertion mutations in order over time. CHYRON stands for Cell HistorY Recording by Ordered iNsertion.